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5ZVM

Crystal Structure of the Human Coronavirus SARS HR1 motif in complex with pan-CoVs inhibitor EK1

Summary for 5ZVM
Entry DOI10.2210/pdb5zvm/pdb
Related5ZUV 5ZVK
DescriptorSpike glycoprotein, pan-CoV inhibitory peptide EK1 (2 entities in total)
Functional Keywordssars, spike protein, s2 domain, hr1 motif, pan-coronavirus, viral protein-inhibitor complex, viral protein/inhibitor
Biological sourceHuman SARS coronavirus (SARS-CoV)
More
Total number of polymer chains6
Total formula weight40866.67
Authors
Yan, L.,Yang, B.,Wilson, I.A. (deposition date: 2018-05-11, release date: 2019-04-10, Last modification date: 2023-11-22)
Primary citationXia, S.,Yan, L.,Xu, W.,Agrawal, A.S.,Algaissi, A.,Tseng, C.K.,Wang, Q.,Du, L.,Tan, W.,Wilson, I.A.,Jiang, S.,Yang, B.,Lu, L.
A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.
Sci Adv, 5:eaav4580-eaav4580, 2019
Cited by
PubMed: 30989115
DOI: 10.1126/sciadv.aav4580
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.3 Å)
Structure validation

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