5YWY

Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and ONO-AE3-208

Summary for 5YWY

Entry DOI	10.2210/pdb5ywy/pdb
Descriptor	Prostaglandin E2 receptor EP4 subtype,Prostaglandin E2 receptor EP4 subtype, Heavy chain of Fab fragment, Light chain of Fab fragment, ... (4 entities in total)
Functional Keywords	g-protein coupled receptor, lipid mediator, functional antibody, signaling protein-immune system complex, membrane protein, signaling protein-immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	91656.93
Authors	Toyoda, Y.,Morimoto, K.,Suno, R.,Horita, S.,Iwata, S.,Kobayashi, T. (deposition date: 2017-11-30, release date: 2018-12-05, Last modification date: 2018-12-19)
Primary citation	Toyoda, Y.,Morimoto, K.,Suno, R.,Horita, S.,Yamashita, K.,Hirata, K.,Sekiguchi, Y.,Yasuda, S.,Shiroishi, M.,Shimizu, T.,Urushibata, Y.,Kajiwara, Y.,Inazumi, T.,Hotta, Y.,Asada, H.,Nakane, T.,Shiimura, Y.,Nakagita, T.,Tsuge, K.,Yoshida, S.,Kuribara, T.,Hosoya, T.,Sugimoto, Y.,Nomura, N.,Sato, M.,Hirokawa, T.,Kinoshita, M.,Murata, T.,Takayama, K.,Yamamoto, M.,Narumiya, S.,Iwata, S.,Kobayashi, T. Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface. Nat. Chem. Biol., 15:18-26, 2019 Cited by PubMed: 30510193 DOI: 10.1038/s41589-018-0131-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation