5Y1Y

Complex structure of nitroxoline with the first bromodomain of BRD4

Summary for 5Y1Y

• Entry DOI: 10.2210/pdb5y1y/pdb
• Descriptor: Bromodomain-containing protein 4, 5-nitroquinolin-8-ol (3 entities in total)
• Functional Keywords: brd4 inhibitor approved drugs, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 1
• Total formula weight: 15073.34

Authors

Jiang, H.,Luo, C. (deposition date: 2017-07-21, release date: 2017-11-15, Last modification date: 2024-03-27)

• Primary citation: Jiang, H.,Xing, J.,Wang, C.,Zhang, H.,Yue, L.,Wan, X.,Chen, W.,Ding, H.,Xie, Y.,Tao, H.,Chen, Z.,Jiang, H.,Chen, K.,Chen, S.,Zheng, M.,Zhang, Y.,Luo, C.; Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues.; Org. Biomol. Chem., 15:9352-9361, 2017; PubMed: 29087414; DOI: 10.1039/c7ob02369c

Experimental method

X-RAY DIFFRACTION (1.912 Å)