5XZR

The atomic structure of SHP2 E76A mutant in complex with allosteric inhibitor 9b

Summary for 5XZR

• Entry DOI: 10.2210/pdb5xzr/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11, 4-(3-phenylphenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3-thiazol-2-amine (3 entities in total)
• Functional Keywords: phosphatase, sh2 domain, allosteric inhibitor, cancer, signaling protein, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q06124
• Total number of polymer chains: 1
• Total formula weight: 64242.55

Authors

Li, D.,Xie, J.,Zhu, J.,Liu, C. (deposition date: 2017-07-13, release date: 2017-12-13, Last modification date: 2023-11-22)

• Primary citation: Xie, J.,Si, X.,Gu, S.,Wang, M.,Shen, J.,Li, H.,Shen, J.,Li, D.,Fang, Y.,Liu, C.,Zhu, J.; Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.; J. Med. Chem., 60:10205-10219, 2017; PubMed: 29155585; DOI: 10.1021/acs.jmedchem.7b01520

Experimental method

X-RAY DIFFRACTION (2.8 Å)