5XYY

The structure of p38 alpha in complex with a triazol inhibitor

Summary for 5XYY

Entry DOI	10.2210/pdb5xyy/pdb
Descriptor	Mitogen-activated protein kinase 14, 3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-4H-1,2,4-triazol-3-yl)phenol (3 entities in total)
Functional Keywords	p38 map kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	43833.28
Authors	Wang, Y.L.,Sun, Y.Z.,Cao, R.,Liu, D.,Li, L.,Qi, X.B.,Huang, N. (deposition date: 2017-07-11, release date: 2018-01-17, Last modification date: 2024-04-10)
Primary citation	Wang, Y.,Sun, Y.,Cao, R.,Liu, D.,Xie, Y.,Li, L.,Qi, X.,Huang, N. In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery. J. Med. Chem., 60:8552-8564, 2017 Cited by PubMed: 28945083 DOI: 10.1021/acs.jmedchem.7b01075 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation