5XG4

Crystal structure of uPA in complex with quercetin

Summary for 5XG4

• Entry DOI: 10.2210/pdb5xg4/pdb
• Descriptor: Urokinase-type plasminogen activator, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, ... (4 entities in total)
• Functional Keywords: serine proteases, upa, pepetide inhibitors, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P00749
• Total number of polymer chains: 1
• Total formula weight: 28284.17

Authors

Jiang, L.,Huang, M. (deposition date: 2017-04-11, release date: 2017-07-26, Last modification date: 2023-11-22)

• Primary citation: Xue, G.,Gong, L.,Yuan, C.,Xu, M.,Wang, X.,Jiang, L.,Huang, M.; A structural mechanism of flavonoids in inhibiting serine proteases; Food Funct, 8:2437-2443, 2017; PubMed: 28644504; DOI: 10.1039/c6fo01825d

Experimental method

X-RAY DIFFRACTION (3 Å)