5X8W

Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain.

Summary for 5X8W

Entry DOI	10.2210/pdb5x8w/pdb
Related	5X8Q 5X8S 5X8U 5X8X
Descriptor	Nuclear receptor ROR-gamma, Nuclear receptor coactivator 1 (3 entities in total)
Functional Keywords	inhibitor, binary complex, nuclear receptor, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	31530.37
Authors	Noguchi, M.,Nomura, A.,Murase, K.,Doi, S.,Yamaguchi, K.,Adachi, T. (deposition date: 2017-03-03, release date: 2017-06-07, Last modification date: 2023-11-22)
Primary citation	Noguchi, M.,Nomura, A.,Murase, K.,Doi, S.,Yamaguchi, K.,Hirata, K.,Shiozaki, M.,Hirashima, S.,Kotoku, M.,Yamaguchi, T.,Katsuda, Y.,Steensma, R.,Li, X.,Tao, H.,Tse, B.,Fenn, M.,Babine, R.,Bradley, E.,Crowe, P.,Thacher, S.,Adachi, T.,Kamada, M. Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment Genes Cells, 22:535-551, 2017 Cited by PubMed: 28493531 DOI: 10.1111/gtc.12494 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation