5X0W

Molecular mechanism for the binding between Sharpin and HOIP

Summary for 5X0W

• Entry DOI: 10.2210/pdb5x0w/pdb
• Descriptor: E3 ubiquitin-protein ligase RNF31, Sharpin (2 entities in total)
• Functional Keywords: sharpin, hoip, linear ubiquitination, e3 enzyme, ligase-protein binding complex, ligase/protein binding
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : Q96EP0; Cytoplasm, cytosol : Q9H0F6
• Total number of polymer chains: 8
• Total formula weight: 120700.91

Authors

Liu, J.,Li, F.,Cheng, X.,Pan, L. (deposition date: 2017-01-23, release date: 2017-10-18)

• Primary citation: Liu, J.,Wang, Y.,Gong, Y.,Fu, T.,Hu, S.,Zhou, Z.,Pan, L.; Structural Insights into SHARPIN-Mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly; Cell Rep, 21:27-36, 2017; PubMed: 28978479; DOI: 10.1016/j.celrep.2017.09.031

Experimental method

X-RAY DIFFRACTION (3 Å)