5X0I

Crystal structure of PKM2 R399E mutant complexed with FBP and serine

Summary for 5X0I

• Entry DOI: 10.2210/pdb5x0i/pdb
• Descriptor: Pyruvate kinase PKM, 1,6-di-O-phosphono-beta-D-fructofuranose, SERINE, ... (7 entities in total)
• Functional Keywords: pyruvate kinase, glycolysis, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 243027.35

Authors

Wang, W.C.,Chen, T.J. (deposition date: 2017-01-20, release date: 2018-01-31, Last modification date: 2023-11-22)

• Primary citation: Chen, T.J.,Wang, H.J.,Liu, J.S.,Cheng, H.H.,Hsu, S.C.,Wu, M.C.,Lu, C.H.,Wu, Y.F.,Wu, J.W.,Liu, Y.Y.,Kung, H.J.,Wang, W.C.; Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation.; Commun Biol, 2:105-105, 2019; PubMed: 30911680; DOI: 10.1038/s42003-019-0343-4

Experimental method

X-RAY DIFFRACTION (2.64 Å)