5WNY

DNA polymerase beta substrate complex with incoming 5-FdUTP

Summary for 5WNY

• Entry DOI: 10.2210/pdb5wny/pdb
• Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... (9 entities in total)
• Functional Keywords: dna ligase/dna, transferase, dna ligase-dna, transferase complex
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 48445.95

Authors

Schaich, M.A.,Smith, M.R.,Cloud, A.S.,Holloran, S.M.,Freudenthal, B.D. (deposition date: 2017-08-01, release date: 2017-09-13, Last modification date: 2023-10-04)

• Primary citation: Schaich, M.A.,Smith, M.R.,Cloud, A.S.,Holloran, S.M.,Freudenthal, B.D.; Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues.; Chem. Res. Toxicol., 30:1993-2001, 2017; PubMed: 28862449; DOI: 10.1021/acs.chemrestox.7b00173

Experimental method

X-RAY DIFFRACTION (2.1 Å)