5WNF

X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR

Summary for 5WNF

• Entry DOI: 10.2210/pdb5wnf/pdb
• Related: 5WNE 5WNG 5WNH
• Descriptor: Rho-associated protein kinase 1, 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-N-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1H-1,2,3-triazole-4-carboxamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: rho kinase, kinase inhibitor, phosphorylation, transferase-inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 194211.45

Authors

Li, X. (deposition date: 2017-07-31, release date: 2018-08-01, Last modification date: 2024-03-13)

• Primary citation: Li, X.,Marshall, D.,Sibley, R.,Bosanac, T.,Ginn, J.,Kugler, S.,Gautschi, E.,Molinaro, T.,Soleymanzadeh, L.,Shih, C.K.,Young, E.R.R.; Novel mechanism of Rho kinase selectivity: beyond the ATP pocket; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)