5WEA

Human Argonaute2 Helix-7 Mutant

Summary for 5WEA

• Entry DOI: 10.2210/pdb5wea/pdb
• Descriptor: Protein argonaute-2, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*U)-3'), PHENOL, ... (4 entities in total)
• Functional Keywords: argonaute, rna binding, rna silencing, microrna, hydrolase, hydrolase-rna complex, hydrolase/rna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 99959.76

Authors

Schirle, N.T.,Klum, S.M.,MacRae, I.J. (deposition date: 2017-07-08, release date: 2017-11-22, Last modification date: 2023-10-04)

• Primary citation: Klum, S.M.,Chandradoss, S.D.,Schirle, N.T.,Joo, C.,MacRae, I.J.; Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition.; EMBO J., 37:75-88, 2018; PubMed: 28939659; DOI: 10.15252/embj.201796474

Experimental method

X-RAY DIFFRACTION (3.12 Å)