5WB7

Crystal structure of the epidermal growth factor receptor extracellular region in complex with epiregulin

Summary for 5WB7

• Entry DOI: 10.2210/pdb5wb7/pdb
• Descriptor: Epidermal growth factor receptor, Proepiregulin, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: receptor tyrosine kinase, growth factor, signaling, membrane protein, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 260397.57

Authors

Freed, D.M.,Bessman, N.J.,Ferguson, K.M.,Lemmon, M.A. (deposition date: 2017-06-28, release date: 2017-10-18, Last modification date: 2023-10-04)

• Primary citation: Freed, D.M.,Bessman, N.J.,Kiyatkin, A.,Salazar-Cavazos, E.,Byrne, P.O.,Moore, J.O.,Valley, C.C.,Ferguson, K.M.,Leahy, D.J.,Lidke, D.S.,Lemmon, M.A.; EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.; Cell, 171:683-695.e18, 2017; PubMed: 28988771; DOI: 10.1016/j.cell.2017.09.017

Experimental method

X-RAY DIFFRACTION (2.941 Å)