5W9D
Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S Mutant in Complex with Endoxifen
Summary for 5W9D
Entry DOI | 10.2210/pdb5w9d/pdb |
Descriptor | Estrogen receptor, Endoxifen (3 entities in total) |
Functional Keywords | breast cancer, selective estrogen receptor modulator, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 57457.39 |
Authors | Fanning, S.W.,Greene, G.L. (deposition date: 2017-06-23, release date: 2017-10-11, Last modification date: 2023-10-04) |
Primary citation | Maximov, P.Y.,Abderrahman, B.,Fanning, S.W.,Sengupta, S.,Fan, P.,Curpan, R.F.,Rincon, D.M.Q.,Greenland, J.A.,Rajan, S.S.,Greene, G.L.,Jordan, V.C. Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer. Mol. Pharmacol., 94:812-822, 2018 Cited by PubMed: 29739819DOI: 10.1124/mol.117.111385 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6464 Å) |
Structure validation
Download full validation report