5W8V

HUMAN HGPRT in complex with [(2-[(guanin-9-yl)methyl]propane-1,3-diyl)bis(oxy)]bis(methylene)diphosphonic acid

Summary for 5W8V

Entry DOI	10.2210/pdb5w8v/pdb
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, {[(2R)-2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-3-(2-phosphonoethoxy)propoxy]methyl}phosphonic acid, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	6-oxopurine; phosphoribosyltransferase; hypoxanthine; guanine; nucleoside phosphonate, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P00492
Total number of polymer chains	4
Total formula weight	98753.98
Authors	Guddat, L.W.,Keough, D.T. (deposition date: 2017-06-22, release date: 2017-08-30, Last modification date: 2024-03-13)
Primary citation	Spacek, P.,Keough, D.T.,Chavchich, M.,Dracinsky, M.,Janeba, Z.,Naesens, L.,Edstein, M.D.,Guddat, L.W.,Hockova, D. Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase. J. Med. Chem., 60:7539-7554, 2017 Cited by PubMed: 28813147 DOI: 10.1021/acs.jmedchem.7b00926 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.346 Å)

Structure validation