5W4R

Structure of RORgt bound to a tertiary alcohol

Summary for 5W4R

• Entry DOI: 10.2210/pdb5w4r/pdb
• Related: 5W4V
• Descriptor: Nuclear receptor ROR-gamma, 1-{4-[(R)-(4-chloro-2-methoxy-3-{[4-(1H-pyrazol-1-yl)phenyl]methyl}quinolin-6-yl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]piperidin-1-yl}ethan-1-one (3 entities in total)
• Functional Keywords: rorgt nuclear hormone receptor, nuclear protein
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P51449
• Total number of polymer chains: 2
• Total formula weight: 51628.51

Authors

Spurlino, J. (deposition date: 2017-06-12, release date: 2017-12-27, Last modification date: 2024-03-13)

• Primary citation: Barbay, J.K.,Cummings, M.D.,Abad, M.,Castro, G.,Kreutter, K.D.,Kummer, D.A.,Maharoof, U.,Milligan, C.,Nishimura, R.,Pierce, J.,Schalk-Hihi, C.,Spurlino, J.,Tanis, V.M.,Urbanski, M.,Venkatesan, H.,Wang, A.,Woods, C.,Wolin, R.,Xue, X.,Edwards, J.P.,Fourie, A.M.,Leonard, K.; 6-Substituted quinolines as ROR gamma t inverse agonists.; Bioorg. Med. Chem. Lett., 27:5277-5283, 2017; PubMed: 29079472; DOI: 10.1016/j.bmcl.2017.10.027

Experimental method

X-RAY DIFFRACTION (3.002 Å)