5VYK

Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1

Summary for 5VYK

Entry DOI	10.2210/pdb5vyk/pdb
Descriptor	Chimera protein of BRS domain of BRAF and CC-SAM domain of KSR1,Serine/threonine-protein kinase B-raf, GLYCEROL (3 entities in total)
Functional Keywords	braf, ksr1, brs, cc-sam, complex, kinase, pseudokinase, signaling., signaling protein
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : P15056
Total number of polymer chains	2
Total formula weight	51351.98
Authors	Maisonneuve, P.,Kurinov, I.,Marullo, S.A.,Lavoie, H.,Thevakumaran, N.,Sahmi, M.,Jin, T.,Therrien, M.,SIcheri, F. (deposition date: 2017-05-25, release date: 2018-02-14, Last modification date: 2024-03-13)
Primary citation	Lavoie, H.,Sahmi, M.,Maisonneuve, P.,Marullo, S.A.,Thevakumaran, N.,Jin, T.,Kurinov, I.,Sicheri, F.,Therrien, M. MEK drives BRAF activation through allosteric control of KSR proteins. Nature, 554:549-553, 2018 Cited by PubMed: 29433126 DOI: 10.1038/nature25478 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.749 Å)

Structure validation