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5VSC

Structure of human G9a SET-domain (EHMT2) in complex with inhibitor 13

Summary for 5VSC
Entry DOI10.2210/pdb5vsc/pdb
Related5VSD 5VSE 5VSF
DescriptorHistone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ... (5 entities in total)
Functional Keywordsprotein-small molecule inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : Q96KQ7
Total number of polymer chains2
Total formula weight65533.10
Authors
Babault, N.,Xiong, Y.,Liu, J.,Jin, J. (deposition date: 2017-05-11, release date: 2017-07-12, Last modification date: 2023-10-04)
Primary citationXiong, Y.,Li, F.,Babault, N.,Wu, H.,Dong, A.,Zeng, H.,Chen, X.,Arrowsmith, C.H.,Brown, P.J.,Liu, J.,Vedadi, M.,Jin, J.
Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.
Bioorg. Med. Chem., 25:4414-4423, 2017
Cited by
PubMed: 28662962
DOI: 10.1016/j.bmc.2017.06.021
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation

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