5VS1

Human DNA polymerase beta pre-catalytic 8-oxoG:dA extension complex with dTTP bound in non-planar conformation

Summary for 5VS1

• Entry DOI: 10.2210/pdb5vs1/pdb
• Related: 5VRX 5VRY 5VRZ 5VS0 5VS2 5VS3 5VS4
• Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*AP*(8OG)P*GP*CP*GP*CP*AP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*TP*GP*CP*GP*CP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... (8 entities in total)
• Functional Keywords: polymerase, 8-oxoguanine, ber, transferase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 49349.44

Authors

Reed, A.J.,Suo, Z. (deposition date: 2017-05-11, release date: 2017-07-19, Last modification date: 2023-10-04)

• Primary citation: Reed, A.J.,Suo, Z.; Time-Dependent Extension from an 8-Oxoguanine Lesion by Human DNA Polymerase Beta.; J. Am. Chem. Soc., 139:9684-9690, 2017; PubMed: 28682600; DOI: 10.1021/jacs.7b05048

Experimental method

X-RAY DIFFRACTION (2.5 Å)