5VQP

Crystal structure of human pro-TGF-beta1

Summary for 5VQP

Entry DOI	10.2210/pdb5vqp/pdb
Descriptor	Transforming growth factor beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
Functional Keywords	latency, furin cleavage, prodomain/growth-factor swapping, homodimer, cytokine
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	42075.91
Authors	Zhao, B.,Xu, S.,Dong, X.,Lu, C.,Springer, T.A. (deposition date: 2017-05-09, release date: 2017-11-15, Last modification date: 2023-10-04)
Primary citation	Zhao, B.,Xu, S.,Dong, X.,Lu, C.,Springer, T.A. Prodomain-growth factor swapping in the structure of pro-TGF-beta 1. J. Biol. Chem., 293:1579-1589, 2018 Cited by PubMed: 29109152 DOI: 10.1074/jbc.M117.809657 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation