5VEE

PAK4 kinase domain in complex with FRAX486

Summary for 5VEE

• Entry DOI: 10.2210/pdb5vee/pdb
• Related: 5VED 5VEE
• Descriptor: Serine/threonine-protein kinase PAK 4, 6-(2,4-dichlorophenyl)-8-ethyl-2-{[3-fluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one (2 entities in total)
• Functional Keywords: kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 36539.14

Authors

Zhang, E.Y.,Ha, B.H.,Boggon, T.J. (deposition date: 2017-04-04, release date: 2017-10-18, Last modification date: 2023-10-04)

• Primary citation: Zhang, E.Y.,Ha, B.H.,Boggon, T.J.; PAK4 crystal structures suggest unusual kinase conformational movements.; Biochim. Biophys. Acta, 1866:356-365, 2018; PubMed: 28993291; DOI: 10.1016/j.bbapap.2017.10.004

Experimental method

X-RAY DIFFRACTION (2.5 Å)