5VCZ

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Bosutinib isomer

Summary for 5VCZ

Entry DOI	10.2210/pdb5vcz/pdb
Related	5VCV 5VCW 5VCX 5VCY 5VD0 5VD1 5VD3
Descriptor	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, 4-[(3,5-DICHLORO-4-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	kinase domain, cell cycle, tyrosine- and threonine-specific kinase, membrane-associated protein kinase, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35445.04
Authors	Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2017-04-01, release date: 2017-08-23, Last modification date: 2023-10-04)
Primary citation	Zhu, J.Y.,Cuellar, R.A.,Berndt, N.,Lee, H.E.,Olesen, S.H.,Martin, M.P.,Jensen, J.T.,Georg, G.I.,Schonbrunn, E. Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J. Med. Chem., 60:7863-7875, 2017 Cited by PubMed: 28792760 DOI: 10.1021/acs.jmedchem.7b00996 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation