5VCW

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Pelitinib

Summary for 5VCW

• Entry DOI: 10.2210/pdb5vcw/pdb
• Related: 5VCV 5VCX 5VCY 5VCZ 5VD0 5VD1 5VD3
• Descriptor: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide, SULFATE ION, ... (5 entities in total)
• Functional Keywords: kinase domain, cell cycle, tyrosine- and threonine-specific kinase, membrane-associated protein kinase, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 70660.70

Authors

Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2017-04-01, release date: 2017-08-23, Last modification date: 2023-10-04)

• Primary citation: Zhu, J.Y.,Cuellar, R.A.,Berndt, N.,Lee, H.E.,Olesen, S.H.,Martin, M.P.,Jensen, J.T.,Georg, G.I.,Schonbrunn, E.; Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.; J. Med. Chem., 60:7863-7875, 2017; PubMed: 28792760; DOI: 10.1021/acs.jmedchem.7b00996

Experimental method

X-RAY DIFFRACTION (2.25 Å)