5V62

Phospho-ERK2 bound to bivalent inhibitor SBP3

Summary for 5V62

• Entry DOI: 10.2210/pdb5v62/pdb
• Related: 5V60 5V61
• Descriptor: Mitogen-activated protein kinase 1, Ribosomal protein S6 kinase alpha-1, GLYCEROL, ... (6 entities in total)
• Functional Keywords: kinase, mapk, phosphorylation, cancer, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 44298.80

Authors

Lechtenberg, B.C.,Riedl, S.J. (deposition date: 2017-03-15, release date: 2017-07-26, Last modification date: 2019-12-04)

• Primary citation: Lechtenberg, B.C.,Mace, P.D.,Sessions, E.H.,Williamson, R.,Stalder, R.,Wallez, Y.,Roth, G.P.,Riedl, S.J.,Pasquale, E.B.; Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.; ACS Med Chem Lett, 8:726-731, 2017; PubMed: 28740606; DOI: 10.1021/acsmedchemlett.7b00127

Experimental method

X-RAY DIFFRACTION (1.9 Å)