5V03
A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA
Summary for 5V03
Entry DOI | 10.2210/pdb5v03/pdb |
Related | 5V02 |
Descriptor | Small conductance calcium-activated potassium channel protein 2, Calmodulin, SULFATE ION, ... (6 entities in total) |
Functional Keywords | calcium-activated ion channels, activator, calmodulin, transport protein-metal binding protein complex, transport protein/metal binding protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Membrane; Multi-pass membrane protein: Q9H2S1 |
Total number of polymer chains | 2 |
Total formula weight | 29571.92 |
Authors | |
Primary citation | Cho, L.T.,Alexandrou, A.J.,Torella, R.,Knafels, J.,Hobbs, J.,Taylor, T.,Loucif, A.,Konopacka, A.,Bell, S.,Stevens, E.B.,Pandit, J.,Horst, R.,Withka, J.M.,Pryde, D.C.,Liu, S.,Young, G.T. An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes. Structure, 26:533-544.e3, 2018 Cited by PubMed: 29576321DOI: 10.1016/j.str.2018.02.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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