5UT3

JAK2 JH2 in complex with IKK-2 Inhibitor VI

Summary for 5UT3

Entry DOI	10.2210/pdb5ut3/pdb
Descriptor	Tyrosine-protein kinase JAK2, 5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE, GLYCEROL, ... (5 entities in total)
Functional Keywords	pseudokinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33717.59
Authors	Puleo, D.E.,Schlessinger, J. (deposition date: 2017-02-14, release date: 2017-06-07, Last modification date: 2023-10-04)
Primary citation	Puleo, D.E.,Kucera, K.,Hammaren, H.M.,Ungureanu, D.,Newton, A.S.,Silvennoinen, O.,Jorgensen, W.L.,Schlessinger, J. Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders. ACS Med Chem Lett, 8:618-621, 2017 Cited by PubMed: 28626521 DOI: 10.1021/acsmedchemlett.7b00153 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.501 Å)

Structure validation