5UR1

FGFR1 kinase domain complex with SN37333 in reversible binding mode

Summary for 5UR1

• Entry DOI: 10.2210/pdb5ur1/pdb
• Related: 5UOK 5UOL 5UOM 5UON
• Descriptor: Fibroblast growth factor receptor 1, 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{1-[4-(dimethylamino)but-2-enoyl]piperidin-4-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (3 entities in total)
• Functional Keywords: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P11362
• Total number of polymer chains: 2
• Total formula weight: 71988.35

Authors

Yosaatmadja, Y.,Paik, W.-K.,Smaill, J.B.,Squire, C.J. (deposition date: 2017-02-09, release date: 2017-05-31, Last modification date: 2023-10-04)

• Primary citation: Li, X.,Guise, C.P.,Taghipouran, R.,Yosaatmadja, Y.,Ashoorzadeh, A.,Paik, W.K.,Squire, C.J.,Jiang, S.,Luo, J.,Xu, Y.,Tu, Z.C.,Lu, X.,Ren, X.,Patterson, A.V.,Smaill, J.B.,Ding, K.; 2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors.; Eur J Med Chem, 135:531-543, 2017; PubMed: 28521156; DOI: 10.1016/j.ejmech.2017.04.049

Experimental method

X-RAY DIFFRACTION (2.2 Å)