5UQV

USP7 in complex with GNE6640 (4-(2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol)

Summary for 5UQV

• Entry DOI: 10.2210/pdb5uqv/pdb
• Related: 5UQX
• Descriptor: Ubiquitin carboxyl-terminal hydrolase 7, 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl]phenol (2 entities in total)
• Functional Keywords: hausp, usp7, sbdd, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q93009
• Total number of polymer chains: 2
• Total formula weight: 85614.67

Authors

Murray, J.M.,Rouge, L. (deposition date: 2017-02-08, release date: 2017-10-25, Last modification date: 2023-10-04)

• Primary citation: Kategaya, L.,Di Lello, P.,Rouge, L.,Pastor, R.,Clark, K.R.,Drummond, J.,Kleinheinz, T.,Lin, E.,Upton, J.P.,Prakash, S.,Heideker, J.,McCleland, M.,Ritorto, M.S.,Alessi, D.R.,Trost, M.,Bainbridge, T.W.,Kwok, M.C.M.,Ma, T.P.,Stiffler, Z.,Brasher, B.,Tang, Y.,Jaishankar, P.,Hearn, B.R.,Renslo, A.R.,Arkin, M.R.,Cohen, F.,Yu, K.,Peale, F.,Gnad, F.,Chang, M.T.,Klijn, C.,Blackwood, E.,Martin, S.E.,Forrest, W.F.,Ernst, J.A.,Ndubaku, C.,Wang, X.,Beresini, M.H.,Tsui, V.,Schwerdtfeger, C.,Blake, R.A.,Murray, J.,Maurer, T.,Wertz, I.E.; USP7 small-molecule inhibitors interfere with ubiquitin binding.; Nature, 550:534-538, 2017; PubMed: 29045385; DOI: 10.1038/nature24006

Experimental method

X-RAY DIFFRACTION (2.84 Å)