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5UOY

Crystal structure of human PDE1B catalytic domain in complex with inhibitor 16j (6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)methyl)-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one)

Summary for 5UOY
Entry DOI10.2210/pdb5uoy/pdb
Related5UP0
DescriptorCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordshydrolase, hydrolase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: Q01064
Total number of polymer chains1
Total formula weight42299.89
Authors
Cedervall, E.P.,Allerston, C.K.,Xu, R.,Sridhar, V.,Barker, R.,Aertgeerts, K. (deposition date: 2017-02-01, release date: 2017-04-26, Last modification date: 2023-10-04)
Primary citationDyck, B.,Branstetter, B.,Gharbaoui, T.,Hudson, A.R.,Breitenbucher, J.G.,Gomez, L.,Botrous, I.,Marrone, T.,Barido, R.,Allerston, C.K.,Cedervall, E.P.,Xu, R.,Sridhar, V.,Barker, R.,Aertgeerts, K.,Schmelzer, K.,Neul, D.,Lee, D.,Massari, M.E.,Andersen, C.B.,Sebring, K.,Zhou, X.,Petroski, R.,Limberis, J.,Augustin, M.,Chun, L.E.,Edwards, T.E.,Peters, M.,Tabatabaei, A.
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.
J. Med. Chem., 60:3472-3483, 2017
Cited by
PubMed: 28406621
DOI: 10.1021/acs.jmedchem.7b00302
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.82 Å)
Structure validation

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