5UN5

Frizzled-8 complex with designed surrogate Wnt agonist, crystal form 1

Summary for 5UN5

• Entry DOI: 10.2210/pdb5un5/pdb
• Related: 5UN6
• Descriptor: Frizzled-8, Designed Wnt agonist B12 (3 entities in total)
• Functional Keywords: signaling protein, signaling protein-de novo protein complex, signaling protein/de novo protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Membrane; Multi-pass membrane protein: Q9H461
• Total number of polymer chains: 4
• Total formula weight: 57572.24

Authors

Janda, C.Y.,Garcia, K.C. (deposition date: 2017-01-30, release date: 2017-05-03, Last modification date: 2023-10-04)

• Primary citation: Janda, C.Y.,Dang, L.T.,You, C.,Chang, J.,de Lau, W.,Zhong, Z.A.,Yan, K.S.,Marecic, O.,Siepe, D.,Li, X.,Moody, J.D.,Williams, B.O.,Clevers, H.,Piehler, J.,Baker, D.,Kuo, C.J.,Garcia, K.C.; Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling.; Nature, 545:234-237, 2017; PubMed: 28467818; DOI: 10.1038/nature22306

Experimental method

X-RAY DIFFRACTION (2.994 Å)