5UJA

Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4

Summary for 5UJA

• Entry DOI: 10.2210/pdb5uja/pdb
• Related: 5UJ9
• EMDB information: 8559 8560
• Descriptor: bovine multidrug resistance protein 1 (MRP1),Multidrug resistance-associated protein 1, (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-( 2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid (2 entities in total)
• Functional Keywords: abc transporter, multidrug resistance, leukotriene c4, ltc4, protein transport
• Biological source: Bos taurus; More
• Total number of polymer chains: 1
• Total formula weight: 160327.70

Authors

Johnson, Z.L.,Chen, J. (deposition date: 2017-01-17, release date: 2017-02-22, Last modification date: 2024-03-13)

• Primary citation: Johnson, Z.L.,Chen, J.; Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1.; Cell, 168:1075-1085.e9, 2017; PubMed: 28238471; DOI: 10.1016/j.cell.2017.01.041

Experimental method

ELECTRON MICROSCOPY (3.34 Å)