5UHI

Structure of RORgt bound to

Summary for 5UHI

Entry DOI	10.2210/pdb5uhi/pdb
Descriptor	Nuclear receptor ROR-gamma, (R)-(4-chloro-2-methoxy-3-{[4-(1H-pyrazol-1-yl)phenyl]methyl}quinolin-6-yl)(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methanol (2 entities in total)
Functional Keywords	nuclear hormone receptor, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P51449
Total number of polymer chains	2
Total formula weight	61346.31
Authors	Spurlino, J.,Abad, M. (deposition date: 2017-01-11, release date: 2017-04-05, Last modification date: 2024-03-06)
Primary citation	Kummer, D.A.,Cummings, M.D.,Abad, M.,Barbay, J.,Castro, G.,Wolin, R.,Kreutter, K.D.,Maharoof, U.,Milligan, C.,Nishimura, R.,Pierce, J.,Schalk-Hihi, C.,Spurlino, J.,Urbanski, M.,Venkatesan, H.,Wang, A.,Woods, C.,Xue, X.,Edwards, J.P.,Fourie, A.M.,Leonard, K. Identification and structure activity relationships of quinoline tertiary alcohol modulators of ROR gamma t. Bioorg. Med. Chem. Lett., 27:2047-2057, 2017 Cited by PubMed: 28318945 DOI: 10.1016/j.bmcl.2017.02.044 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.198 Å)

Structure validation