5UAG

Escherichia coli RNA polymerase mutant - RpoB D516V

Summary for 5UAG

• Entry DOI: 10.2210/pdb5uag/pdb
• Related: 5UAC 5UAH 5UAJ 5UAL 5UAQ
• Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (7 entities in total)
• Functional Keywords: inhibitor, antibiotic, tuberculosis, rifampin, rifamycin, rna polymerase, rifamycin resistant mutation, rpob-d516v, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Escherichia coli (strain K12); More
• Total number of polymer chains: 12
• Total formula weight: 916010.04

Authors

Molodtsov, V.,Scharf, N.T.,Stefan, M.A.,Garcia, G.A.,Murakami, K.S. (deposition date: 2016-12-19, release date: 2017-02-08, Last modification date: 2023-10-04)

• Primary citation: Molodtsov, V.,Scharf, N.T.,Stefan, M.A.,Garcia, G.A.,Murakami, K.S.; Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.; Mol. Microbiol., 103:1034-1045, 2017; PubMed: 28009073; DOI: 10.1111/mmi.13606

Experimental method

X-RAY DIFFRACTION (3.399 Å)