5U6C

Crystal structure of the Mer kinase domain in complex with a macrocyclic inhibitor

Summary for 5U6C

• Entry DOI: 10.2210/pdb5u6c/pdb
• Related: 5U6B
• Descriptor: Tyrosine-protein kinase Mer, (10R)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1H-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one (3 entities in total)
• Functional Keywords: kinase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Membrane ; Single-pass type I membrane protein : Q12866
• Total number of polymer chains: 2
• Total formula weight: 73393.22

Authors

Gajiwala, K.S.,Ferre, R.A. (deposition date: 2016-12-07, release date: 2017-07-26, Last modification date: 2023-10-04)

• Primary citation: Gajiwala, K.S.,Grodsky, N.,Bolanos, B.,Feng, J.,Ferre, R.,Timofeevski, S.,Xu, M.,Murray, B.W.,Johnson, T.W.,Stewart, A.; The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase.; J. Biol. Chem., 292:15705-15716, 2017; PubMed: 28724631; DOI: 10.1074/jbc.M116.771485

Experimental method

X-RAY DIFFRACTION (2.1 Å)