5U5K

Crystal structure of EED in complex with 3-(3-methoxybenzyl)piperidine hydrochloride

Summary for 5U5K

Entry DOI	10.2210/pdb5u5k/pdb
Related	5U5H 5U5T 5U62
Descriptor	Polycomb protein EED, FORMIC ACID, (3R)-3-[(3-methoxyphenyl)methyl]piperidine, ... (4 entities in total)
Functional Keywords	eed, fragment-based generation, oncology, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: O75530
Total number of polymer chains	1
Total formula weight	42607.57
Authors	Bussiere, D.,Shu, W. (deposition date: 2016-12-06, release date: 2017-01-11, Last modification date: 2024-03-06)
Primary citation	Lingel, A.,Sendzik, M.,Huang, Y.,Shultz, M.D.,Cantwell, J.,Dillon, M.P.,Fu, X.,Fuller, J.,Gabriel, T.,Gu, J.,Jiang, X.,Li, L.,Liang, F.,McKenna, M.,Qi, W.,Rao, W.,Sheng, X.,Shu, W.,Sutton, J.,Taft, B.,Wang, L.,Zeng, J.,Zhang, H.,Zhang, M.,Zhao, K.,Lindvall, M.,Bussiere, D.E. Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. J. Med. Chem., 60:415-427, 2017 Cited by PubMed: 27992714 DOI: 10.1021/acs.jmedchem.6b01473 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation