5U1U
Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist A740003
Summary for 5U1U
| Entry DOI | 10.2210/pdb5u1u/pdb |
| Related | 5U1L 5U1V 5U1W 5U1X 5U1Y 5U2H |
| Descriptor | P2X purinoceptor, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-{(1R)-1-[N''-cyano-N'-(quinolin-5-yl)carbamimidamido]-2,2-dimethylpropyl}-2-(3,4-dimethoxyphenyl)acetamide (3 entities in total) |
| Functional Keywords | membrane protein: atp-gated ion channel: allosteric antagonist bound: closed state, membrane protein |
| Biological source | Ailuropoda melanoleuca (Giant panda) |
| Total number of polymer chains | 1 |
| Total formula weight | 39854.41 |
| Authors | Karasawa, A.,Kawate, T. (deposition date: 2016-11-29, release date: 2017-01-11, Last modification date: 2023-10-04) |
| Primary citation | Karasawa, A.,Kawate, T. Structural basis for subtype-specific inhibition of the P2X7 receptor. Elife, 5:-, 2016 Cited by PubMed: 27935479DOI: 10.7554/eLife.22153 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.604 Å) |
Structure validation
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