5U06

Grb7-SH2 with bicyclic peptide inhibitor containing a pY mimetic

Summary for 5U06

• Entry DOI: 10.2210/pdb5u06/pdb
• Related: 5TYI 5U1Q
• Descriptor: Growth factor receptor-bound protein 7, bicyclic peptide inhibitor: LYS-PHE-GLU-GLY-CMF-ASP-ASN-GLU-CST, POTASSIUM ION, ... (4 entities in total)
• Functional Keywords: grb7, sh2 domain, inhibitor, signalling, signaling protein-peptide inhibitor complex, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 59618.91

Authors

Watson, G.M.,Wilce, J.A. (deposition date: 2016-11-22, release date: 2017-11-15, Last modification date: 2020-01-08)

• Primary citation: Watson, G.M.,Kulkarni, K.,Sang, J.,Ma, X.,Gunzburg, M.J.,Perlmutter, P.,Wilce, M.C.J.,Wilce, J.A.; Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.; J. Med. Chem., 60:9349-9359, 2017; PubMed: 29083893; DOI: 10.1021/acs.jmedchem.7b01320

Experimental method

X-RAY DIFFRACTION (2.1 Å)