5TYT

Crystal Structure of the PDZ domain of RhoGEF bound to CXCR2 C-terminal peptide

Summary for 5TYT

Entry DOI	10.2210/pdb5tyt/pdb
Descriptor	Rho guanine nucleotide exchange factor 11, C-X-C chemokine receptor type 2 chimera (2 entities in total)
Functional Keywords	pdz-rhogef, cxcr2, protein binding
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane; Multi-pass membrane protein: P25025
Total number of polymer chains	4
Total formula weight	37423.72
Authors	Spellmon, N.,Holcomb, J.,Niu, A.,Choudhary, V.,Sun, X.,Brunzelle, J.,Li, C.,Yang, Z. (deposition date: 2016-11-21, release date: 2017-02-22, Last modification date: 2023-10-04)
Primary citation	Spellmon, N.,Holcomb, J.,Niu, A.,Choudhary, V.,Sun, X.,Zhang, Y.,Wan, J.,Doughan, M.,Hayden, S.,Hachem, F.,Brunzelle, J.,Li, C.,Yang, Z. Structural basis of PDZ-mediated chemokine receptor CXCR2 scaffolding by guanine nucleotide exchange factor PDZ-RhoGEF. Biochem. Biophys. Res. Commun., 485:529-534, 2017 Cited by PubMed: 28179147 DOI: 10.1016/j.bbrc.2017.02.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.398 Å)

Structure validation