5TYI

Grb7 SH2 with bicyclic peptide containing pY mimetic

Summary for 5TYI

• Entry DOI: 10.2210/pdb5tyi/pdb
• Related: 5U06 5U1Q
• Descriptor: Growth factor receptor-bound protein 7, Peptide inhibitor (3 entities in total)
• Functional Keywords: sh2, inhibitor, bicyclic, signaling protein-peptide complex, signaling protein/peptide
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 59523.71

Authors

Watson, G.M.,Wilce, M.C.J.,Wilce, J.A. (deposition date: 2016-11-20, release date: 2017-11-15, Last modification date: 2023-11-15)

• Primary citation: Watson, G.M.,Kulkarni, K.,Sang, J.,Ma, X.,Gunzburg, M.J.,Perlmutter, P.,Wilce, M.C.J.,Wilce, J.A.; Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.; J. Med. Chem., 60:9349-9359, 2017; PubMed: 29083893; DOI: 10.1021/acs.jmedchem.7b01320

Experimental method

X-RAY DIFFRACTION (2.15 Å)