5TXS

Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-B*1501

Summary for 5TXS

Entry DOI	10.2210/pdb5txs/pdb
Descriptor	HLA class I histocompatibility antigen, B-15 alpha chain, Beta-2-microglobulin, anapestic lymphoma kinase-derived neuroblastoma tumor antigen, ... (4 entities in total)
Functional Keywords	lymphoma kinase-derived neuroblastoma tumor antigen, human major histocompatibility complex class i, mhc-i, complex, immune system
Biological source	Homo sapiens (Human) More
Cellular location	Membrane; Single-pass type I membrane protein: P30464 Secreted . Note=(Microbial infection) In the presence of M: P61769
Total number of polymer chains	3
Total formula weight	47474.62
Authors	Toor, J.,Rao, A.A.,Salama, S.,Tripathi, S.,Haussler, D.,Sgourakis, N.G. (deposition date: 2016-11-17, release date: 2017-11-29, Last modification date: 2023-10-04)
Primary citation	Toor, J.S.,Rao, A.A.,McShan, A.C.,Yarmarkovich, M.,Nerli, S.,Yamaguchi, K.,Madejska, A.A.,Nguyen, S.,Tripathi, S.,Maris, J.M.,Salama, S.R.,Haussler, D.,Sgourakis, N.G. A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations. Front Immunol, 9:99-99, 2018 Cited by PubMed: 29441070 DOI: 10.3389/fimmu.2018.00099 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.697 Å)

Structure validation