5TTG

Crystal structure of catalytic domain of GLP with MS012

Summary for 5TTG

• Entry DOI: 10.2210/pdb5ttg/pdb
• Related: 5TTF
• Descriptor: Histone-lysine N-methyltransferase EHMT1, S-ADENOSYLMETHIONINE, N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine, ... (9 entities in total)
• Functional Keywords: ehmt1, glp, ms012, methyltransferase, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: Q9H9B1
• Total number of polymer chains: 2
• Total formula weight: 68277.61

Authors

DONG, A.,ZENG, H.,LIU, J.,XIONG, Y.,BABAULT, N.,JIN, J.,TEMPEL, W.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,WU, H.,BROWN, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2016-11-03, release date: 2017-02-01, Last modification date: 2023-10-04)

• Primary citation: Xiong, Y.,Li, F.,Babault, N.,Dong, A.,Zeng, H.,Wu, H.,Chen, X.,Arrowsmith, C.H.,Brown, P.J.,Liu, J.,Vedadi, M.,Jin, J.; Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.; J. Med. Chem., 60:1876-1891, 2017; PubMed: 28135087; DOI: 10.1021/acs.jmedchem.6b01645

Experimental method

X-RAY DIFFRACTION (1.66 Å)