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5TTF

Crystal structure of catalytic domain of G9a with MS012

Summary for 5TTF
Entry DOI10.2210/pdb5ttf/pdb
Related5TTG
DescriptorHistone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ... (7 entities in total)
Functional Keywordsehmt2, g9a, bat8, methyltransferase, unc3832, structural genomics, structural genomics consortium, sgc, transferase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : Q96KQ7
Total number of polymer chains4
Total formula weight134878.89
Authors
DONG, A.,ZENG, H.,LIU, J.,XIONG, Y.,BABAULT, N.,JIN, J.,TEMPEL, W.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,WU, H.,BROWN, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2016-11-03, release date: 2016-12-21, Last modification date: 2023-10-04)
Primary citationXiong, Y.,Li, F.,Babault, N.,Dong, A.,Zeng, H.,Wu, H.,Chen, X.,Arrowsmith, C.H.,Brown, P.J.,Liu, J.,Vedadi, M.,Jin, J.
Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
J. Med. Chem., 60:1876-1891, 2017
Cited by
PubMed: 28135087
DOI: 10.1021/acs.jmedchem.6b01645
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.72 Å)
Structure validation

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