5TRS

Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2144

Summary for 5TRS

• Entry DOI: 10.2210/pdb5trs/pdb
• Related: 5TRG 5TRR 5TRY 5TS9
• Related PRD ID: PRD_002256
• Descriptor: Proteasome subunit alpha, Proteasome subunit beta, N-tert-butoxy-N~2~-(5-methyl-1,2-oxazole-3-carbonyl)-L-asparaginyl-O-methyl-N-[(naphthalen-1-yl)methyl]-L-serinamide, ... (4 entities in total)
• Functional Keywords: mycobacterium tuberculosis, proteasome, n, c-capped dipeptide, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mycobacterium tuberculosis; More
• Total number of polymer chains: 28
• Total formula weight: 725197.84

Authors

Hsu, H.-C.,Fan, H.,Singh, P.K.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H. (deposition date: 2016-10-27, release date: 2017-01-11, Last modification date: 2024-03-06)

• Primary citation: Hsu, H.C.,Singh, P.K.,Fan, H.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H.; Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.; Biochemistry, 56:324-333, 2017; PubMed: 27976853; DOI: 10.1021/acs.biochem.6b01107

Experimental method

X-RAY DIFFRACTION (3.08356699278 Å)