5TRR

Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2169

5TRR の概要

• エントリーDOI: 10.2210/pdb5trr/pdb
• 関連するPDBエントリー: 5TRG 5TRS 5TRY 5TS0
• 関連するBIRD辞書のPRD_ID: PRD_002255
• 分子名称: Proteasome subunit alpha, Proteasome subunit beta, N,N-diethyl-N~2~-(3-phenylpropanoyl)-L-asparaginyl-N-[(naphthalen-1-yl)methyl]-L-alaninamide, ... (4 entities in total)
• 機能のキーワード: n, c-capped dipeptides, mycobacterium tuberculosis, proteasome inhibitors, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Mycobacterium tuberculosis; 詳細
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 724876.56

構造登録者

Hsu, H.-C.,Fan, H.,Singh, P.K.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H. (登録日: 2016-10-27, 公開日: 2017-01-11, 最終更新日: 2023-10-04)

• 主引用文献: Hsu, H.C.,Singh, P.K.,Fan, H.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H.; Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.; Biochemistry, 56:324-333, 2017; PubMed: 27976853; DOI: 10.1021/acs.biochem.6b01107

実験手法

X-RAY DIFFRACTION (3.103 Å)