5TOK

Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-L66

Summary for 5TOK

• Entry DOI: 10.2210/pdb5tok/pdb
• Related: 5TOJ
• Descriptor: Fusion glycoprotein F0, Fibritin chimera, Single-domain antibody F-VHH-L66, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: fusion, nanobody, immunoglobulin fold, complex, viral protein-immune system complex, viral protein/immune system
• Biological source: Human respiratory syncytial virus; More
• Total number of polymer chains: 6
• Total formula weight: 226964.31

Authors

Gilman, M.S.A.,Kabeche, S.C.,McLellan, J.S. (deposition date: 2016-10-17, release date: 2017-02-22, Last modification date: 2023-10-04)

• Primary citation: Rossey, I.,Gilman, M.S.,Kabeche, S.C.,Sedeyn, K.,Wrapp, D.,Kanekiyo, M.,Chen, M.,Mas, V.,Spitaels, J.,Melero, J.A.,Graham, B.S.,Schepens, B.,McLellan, J.S.,Saelens, X.; Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.; Nat Commun, 8:14158-14158, 2017; PubMed: 28194013; DOI: 10.1038/ncomms14158

Experimental method

X-RAY DIFFRACTION (3.8 Å)