5TN5

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the AC-ring estrogen, (1S,3aS,5S,7aS)-5-(4-hydroxyphenyl)-7a-methyloctahydro-1H-inden-1-ol

5TN5 の概要

• エントリーDOI: 10.2210/pdb5tn5/pdb
• 関連するPDBエントリー: 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN6 5TN7 5TN8
• 分子名称: Estrogen receptor, Nuclear receptor coactivator 2, (1S,3aS,5S,7aS)-5-(4-hydroxyphenyl)-7a-methyloctahydro-1H-inden-1-ol, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372; Nucleus: Q15596
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 62251.49

構造登録者

Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W. (登録日: 2016-10-13, 公開日: 2017-01-18, 最終更新日: 2024-03-06)

• 主引用文献: Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Wright, N.J.,Minutolo, F.,Rangarajan, E.S.,Izard, T.,Yao, X.Q.,Grant, B.J.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W.; Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.; Cell Chem Biol, 24:35-45, 2017; PubMed: 28042045; DOI: 10.1016/j.chembiol.2016.11.014

実験手法

X-RAY DIFFRACTION (1.892 Å)