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5TMM

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC analog, (E)-6-(4-((1R,4S,6R)-6-((4-bromophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenyl)hex-5-enoic acid

Summary for 5TMM
Entry DOI10.2210/pdb5tmm/pdb
Related5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8
DescriptorEstrogen receptor, Nuclear receptor coactivator 2, 6-{4-[(1S,4S,6S)-6-[(4-bromophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenyl}hex-5-enoic acid, ... (4 entities in total)
Functional Keywordsnuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription
Biological sourceHomo sapiens (Human)
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Cellular locationIsoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Nucleus: Q15596
Total number of polymer chains4
Total formula weight62981.80
Authors
Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2016-10-13, release date: 2017-01-18, Last modification date: 2024-03-06)
Primary citationNwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Wright, N.J.,Minutolo, F.,Rangarajan, E.S.,Izard, T.,Yao, X.Q.,Grant, B.J.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W.
Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24:35-45, 2017
Cited by
PubMed: 28042045
DOI: 10.1016/j.chembiol.2016.11.014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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