5THP
Rhodocetin in complex with the integrin alpha2-A domain
Summary for 5THP
| Entry DOI | 10.2210/pdb5thp/pdb |
| Descriptor | Snaclec rhodocetin subunit gamma, Snaclec rhodocetin subunit delta, Integrin alpha-2, ... (9 entities in total) |
| Functional Keywords | c-type lectin, integrin, venom, coagulation, cell adhesion |
| Biological source | Homo sapiens (Human) More |
| Cellular location | Secreted: D2YW39 D2YW40 Membrane; Single-pass type I membrane protein: P17301 |
| Total number of polymer chains | 18 |
| Total formula weight | 329928.14 |
| Authors | McDougall, M.,Orriss, G.L.,Stetefeld, J. (deposition date: 2016-09-30, release date: 2017-08-02, Last modification date: 2023-10-04) |
| Primary citation | Eble, J.A.,McDougall, M.,Orriss, G.L.,Niland, S.,Johanningmeier, B.,Pohlentz, G.,Meier, M.,Karrasch, S.,Estevao-Costa, M.I.,Martins Lima, A.,Stetefeld, J. Dramatic and concerted conformational changes enable rhodocetin to block alpha 2 beta 1 integrin selectively. PLoS Biol., 15:e2001492-e2001492, 2017 Cited by PubMed: 28704364DOI: 10.1371/journal.pbio.2001492 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.006 Å) |
Structure validation
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