5TFT

Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex

Summary for 5TFT

Entry DOI	10.2210/pdb5tft/pdb
Related	5T1U 5TFT
Descriptor	Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ZINC ION, ... (5 entities in total)
Functional Keywords	cyp2d6, p450 2d6, cytochrome p450, monooxygenase, bace1, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	219232.82
Authors	Hsu, M.H.,Johnson, E.F. (deposition date: 2016-09-26, release date: 2017-01-11, Last modification date: 2023-10-04)
Primary citation	Butler, C.R.,Ogilvie, K.,Martinez-Alsina, L.,Barreiro, G.,Beck, E.M.,Nolan, C.E.,Atchison, K.,Benvenuti, E.,Buzon, L.,Doran, S.,Gonzales, C.,Helal, C.J.,Hou, X.,Hsu, M.H.,Johnson, E.F.,Lapham, K.,Lanyon, L.,Parris, K.,O'Neill, B.T.,Riddell, D.,Robshaw, A.,Vajdos, F.,Brodney, M.A. Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality. J. Med. Chem., 60:386-402, 2017 Cited by PubMed: 27997172 DOI: 10.1021/acs.jmedchem.6b01451 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.71 Å)

Structure validation