5TCO

Human p38 MAP Kinase in Complex with Dibenzosuberone Compound 1

Summary for 5TCO

• Entry DOI: 10.2210/pdb5tco/pdb
• Related: 5TBE
• Descriptor: Mitogen-activated protein kinase 14, 3-[(3-benzamido-4-fluoranyl-phenyl)amino]-~{N}-(2-morpholin-4-ylethyl)-11-oxidanylidene-5,6-dihydrodibenzo[1,2-~{d}:1',2'-~{f}][7]annulene-9-carboxamide, octyl beta-D-glucopyranoside, ... (4 entities in total)
• Functional Keywords: inhibitor, dibenzosuberone, human p38 map kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 42446.45

Authors

Mayer-Wrangowski, S.C.,Rauh, D. (deposition date: 2016-09-15, release date: 2017-04-19, Last modification date: 2020-07-29)

• Primary citation: Wentsch, H.K.,Walter, N.M.,Buhrmann, M.,Mayer-Wrangowski, S.,Rauh, D.,Zaman, G.J.R.,Willemsen-Seegers, N.,Buijsman, R.C.,Henning, M.,Dauch, D.,Zender, L.,Laufer, S.; Optimized Target Residence Time: Type I1/2 Inhibitors for p38 alpha MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.; Angew. Chem. Int. Ed. Engl., 56:5363-5367, 2017; PubMed: 28397331; DOI: 10.1002/anie.201701185

Experimental method

X-RAY DIFFRACTION (2.1 Å)